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If confirmed in humans, this result may have translational significance

PDL1, CTLA4, TIM3, and LAG3-mediated signaling lowers effector T cell proliferation and cytotoxic effects on cancer cells [50], while increasing effector T cell anergy and exhaustion [48]

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Zhu et al., 2018).Under osmotic and temperature stress, AOX pathway regulation of ROS through redox couples related to malate valve and antioxidant system (Wang and Vanlerberghe, 2013)