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Qian, R., Ding, L

Activation of astrocyte MOR elevates cytosolic calcium ions, leading to rapid glutamate release, and further regulating neuronal activity (175, 176)

175 For the PPP enzymes, recent studies have discovered some inhibitors targeting on G6PD, such as NADP + analogs, the competitive inhibitor 6-aminonicotinamide (6-AN), noncompetitive inhibitors epiandrosterone and dehydroepiandrosterone (DHEA) which reduces the availability of NADPH and inhibits the cell growth

Studies on glucose metabolism and insulin secretion conducted in p43 knockout mice with preserved expression of other THs receptors have revealed impaired insulin and glucagon secretion by the pancreas, with no effect of glucose on insulin secretion, decreased density of the islets of Langerhans, reduced expression of GLUT2 and Kir 6.2 protein - a subunit of the ATP-dependent K+ channel (32)