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HUBERMAN: My whole purpose in doing this episode is to highlight how these different molecules ought to work, how they've been shown to work in animal models, and therefore how they might be working in humans

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Although peripheral 5-HT cannot cross the BBB directly, it influences CNS function indirectly by activating vagal afferent fibers, modulating immune cells, and affecting tryptophan availability ( 4.1.2 The GABA pathway Beyond the 5-HT system, GABA, as the most abundant inhibitory neurotransmitter in the CNS, has a core role in mood regulation and anxiety control