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Instead, the substance is being moved into the PCAC review pipeline, where independent experts will evaluate whether it should be approved for legal compounding under Section 503A

In comparison, rhGPx3 mutant seems more likely to catalyze the reaction just like GPx4, which is the only monomeric member among the GPx family, due to the fact that the mutant exists as a monomer in its native state

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However, their therapeutic index is often narrowas exemplified by deferoxamine, which, despite being well-studied, is currently limited to treating acute iron poisoning and conditions involving chronic blood transfusions (e.g., thalassemia)