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(v) alternatively, pyruvate may yield acetate through neomorphic activity of pyruvate dehydrogenase complex (or other dehydrogenases) in the presence of reactive oxygen species (ROS) 169,170 , that in turn yields acetyl-CoA by mitochondrial acetyl-CoA synthetase (Fig

Cho S, Lee YH, Park H et al (2001) Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1

These shared proinflammatory lipid signatures point to common pathogenic mechanisms driving multiorgan dysfunction in metabolic-pulmonary comorbidities, offering a mechanistic framework for understanding the shared pathophysiology between DM and COPD (Caughey et al., 2013

Effect of the serum samples on the endothelial cells The endothelial monolayers in 48-well culture plates were exposed for 24 h to the standard culture medium supplemented with the serum sample (20%v/v)