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Chernausek SD, Backeljauw PF, Frane J, Kuntze J, Underwood LE, Group GHISC: Long-term treatment with recombinant insulin-like growth factor (IGF)-I in children with severe IGF-I deficiency due to growth hormone insensitivity

Its remarkable to think how many lives this crucial peptide has saved

1.4 P62-dependent Nrf2 Regulation Additional pieces of evidence suggest that other regulators also may activate the Nrf2 pathway

261,262,263 Cuproptosis as a putative therapeutic target for Wilsons disease As mentioned above, mutations in the ATP7B gene, which encodes the Cu-transporting P-type ATPase ATP7B, are associated with Wilsons disease, a life-threatening disorder in which patients present with progressive Cu accumulation in several tissues, particularly the liver, brain, and cornea